[Randomized intravascular ultrasound comparison between endoprostheses with and without amorphous silicon-carbide].

نویسندگان

  • Luiz Fernando Leite Tanajura
  • J Eduardo M R Sousa
  • Amanda G M R Sousa
  • Alexandre Abizaid
  • João Eduardo T Paula
  • Mariano Albertal
  • Fausto Feres
  • Luiz Alberto P Mattos
  • Rodolfo Staico
  • Ibraim M F Pinto
چکیده

The superiority of coronary stent implantation over percutaneous transluminal balloon angioplasty in virtually all lesion subsets has led to the wide use of stents for the percutaneous treatment of coronary lesions 1,2. However, in-stent restenosis remains as a major limitation 3,4. Recent data suggest that neointimal proliferation, the cornerstone of in-stent restenosis 5,6, is related to the presence of thrombus and degree of inflammation at the stent site7. A potential approach for the prevention of neointimal proliferation is the use of amorphous silicon-carbide (a-SiC), an inactive substance known to have antithrombotic and anti-inflammatory properties 8,9. By coating stents with a-SiC, hemoand biocompatibility of stent prostheses is enhanced, potentially reducing neointimal proliferation. Therefore, the purpose of the CERAMIC trial (randomized intravascular ultrasound Comparison between EndopRostheses with and without AMorphous sIlicon-Carbide for the prevention of coronary restenosis) was to determine whether a-SiC-coated stents prevent intrastent neointimal proliferation in humans.

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عنوان ژورنال:
  • Arquivos brasileiros de cardiologia

دوره 83 Spec No  شماره 

صفحات  -

تاریخ انتشار 2004